In a 1930s Berlin, the infamous criminal Dr. Mabuse, considered a genius of evil, has returned from his confinement. Now, although tormented by madness, he has managed to dictate a diabolical plan from his deathbed. A group of criminals gathers to carry out his legacy, unleashing chaos in the city with a series of crimes that defy law and order. On the other hand, Detective Kriminalkommissar Lessing finds himself in an intense race against time. Obsessed with unraveling the mystery surrounding Mabuse, Lessing immerses himself in a dark world of conspiracies and unleashed passions.