In a world devastated by war and anarchy, John Rambo has been living in exile in the mountains of a remote South American country, far from the memories that haunt him and the violence that has accompanied him throughout his life. However, his tranquility is interrupted when a gang of human traffickers kidnaps a group of native youths, including the daughter of an old friend of Rambo. Motivated by his loyalty and a sense of duty he has never been able to abandon, Rambo is drawn back into a conflict he swore he would never be involved in again.