A brilliant symbology professor, Robert Langdon, wakes up in a hospital in Florence, Italy, without remembering how he got there. The only thing he is clear about is that he is in the middle of a race against time to stop a dangerous plan that threatens to unleash an apocalyptic virus. With the help of a medical doctor, Sienna Brooks, Langdon embarks on a complex journey through famous monuments and Renaissance works of art, where he must decipher clues that reveal a dark secret related to Dante Alighieri and his masterpiece, "The Divine Comedy."
As he delves deeper into the mystery, Langdon realizes that powerful forces are pursuing him, including an enigmatic agent from the World Health Organization who has his own agenda. The tension escalates, and unexpected twists test not only his knowledge and skills but also his ability to trust those around him. Langdon and Sienna must combine their knowledge and ingenuity to find a solution before time runs out and the world faces an imminent catastrophe. In a journey that blends art, science, and literature with pure adrenaline, the film explores the struggle between good and evil, and the eternal quest for truth in a world full of deception and conspiracies.