Imagine two completely opposite men who end up sharing an apartment in New York. Felix Ungar, an obsessive and meticulous newly divorced man, represents order and cleanliness, while Oscar Madison, a laid-back and somewhat messy journalist, lives in total chaos. After his separation, Felix decides to move in with his friend Oscar, hoping to find a fresh start.
However, cohabitation will not be easy. From day one, their personality differences clash hilariously. Oscar can't stand Felix's quirks, which seem to multiply every hour, while Felix cannot understand how Oscar can live amid such disorder. Oscar's apartment lifestyle, filled with parties and negligence, is a complete disaster for Felix's strict nature.
As the plot unfolds, their constant arguments and misunderstandings provide comedic and endearing moments. Yet, amid the laughter, the struggles of love and friendship are explored as both men face their own personal demons. With a backdrop of melancholy, each must learn to accept their differences and even find a balance in their crazy coexistence. Along the way, the film offers a funny and touching glimpse into friendship, loneliness, and the search for happiness in an unpredictable world.