In a typical American high school, Bianca, a smart and fun girl, finds herself trapped in a web of insecurities when her closest friend reveals that she is considered the "Designated Ugly Fat Friend" (DUFF) of the group. Despite being an attractive young woman, the label makes her question her social standing and self-esteem. Determined not to be seen as "the ugly one," Bianca embarks on a mission to reinvent herself and find her own worth.