In the 18th century, in the heart of the South American jungle, a Jesuit priest named Gabriel, played by Jeremy Irons, embarks on an ambitious mission to protect a Guarani indigenous tribe from the dangers of European colonization. Determined to preserve their lands and culture, Gabriel builds a mission in the jungle, where the indigenous people can find refuge and security.
However, peace is fleeting: the Spanish colonial power is willing to erase any trace of resistance. Tension rises when the Spanish governor, pressured by economic interests, attempts to strip the Guarani of their rights. Amidst this conflict, an old friend of Gabriel's, Rodrigo, portrayed by Robert De Niro, emerges—a former mercenary seeking redemption after a dark past. Together, these men of faith and struggle will confront the colonial forces and their own inner demons.
As the mission becomes a symbol of resistance and hope, Gabriel and Rodrigo must decide how far they are willing to go to protect those they have come to love, facing moral dilemmas that challenge their faith and humanity. In an epic journey filled with beauty, tragedy, and spirituality, a tale of redemption and sacrifice unfolds, leaving an indelible mark on their lives and the region's history. The struggle between faith and power serves as the backdrop for a visceral and visually stunning narrative.