In the bustling heart of New York City, a girl named Emily Elizabeth finds herself a bit lonely and yearning for adventure. Her life takes an unexpected turn when, after meeting a mysterious pet vendor, a massive red dog appears in her life—a veteran of a bad day whose sole mission is to make her happy. At first, Clifford seems like just an adorable puppy, but as he grows into a huggable and challenging giant, he becomes the best friend Emily has always wanted. However, having a giant dog comes with its challenges, and the antics of her furry friend soon draw the attention of the authorities and a ruthless company looking to capture him.
As Emily and Clifford embark on wacky adventures together, their bond grows stronger, teaching the girl lessons about love, friendship, and the importance of accepting oneself as one is. Along with her loyal friends and her determined uncle, Emily embarks on an exciting mission to protect Clifford from those who want to separate them. With a touch of magic, humor, and a giant heart, the story shows us how an unbreakable bond can change our perspectives and help us face the greatest challenges, proving that even when things seem insurmountable, together we can always find a way. In the end, Clifford not only becomes Emily's best friend but also her superpower.