In a world where the extraordinary becomes the everyday, a young woman named Susan Murphy experiences a strange incident on her wedding day, getting hit by a meteorite that transforms her into a 15-foot giant. Captured by the government, she is taken to a secret facility where other monsters live, including a funny and clumsy elastic man, a scaly man with a reptilian look, a giant insect with a heart of gold, and a creature of darkness with a touch of madness. When an alien threat led by the evil Gallaxhar decides to invade Earth and capture Susan for his own purposes, she and her new friends have no choice but to band together to save the planet.
Defying expectations, Susan becomes an unexpected heroine, learning to embrace her monstrosity and fight for what is right. With the help of her quirky companions—who demonstrate that true strength comes from friendship and acceptance—they embark on an action-packed and laughter-filled adventure. As they battle the aliens, they all discover that what makes them different is also what makes them special. With humorous and tender moments, the story turns alienation into celebration, showing that being unique is definitely cool. Thus, a group of unconventional monsters becomes humanity's last line of defense against an intergalactic invasion, leaving a lesson about the value of being oneself along the way.