In a world where Pokémon and humans coexist, the story centers on Mewtwo, a legendary Pokémon created in a laboratory from Mew's DNA, who discovers that he is an experiment and an artificial creation. However, Mewtwo is not only powerful but also aware of his own suffering and the injustice he faces. After feeling betrayed by his creators, he decides to escape, searching for his place in a world that sees him as a mere object.
In his journey, Mewtwo encounters Ash Ketchum and his friends, who try to understand his pain and help him. But not everything is peace and reflection; things get complicated when Mewtwo decides that the only way to free himself from the pain of rejection is to confront humanity. With the help of his army of cloned Pokémon, he unleashes an epic battle in an attempt to prove that Pokémon are more valuable than their trainers, challenging the established order of the relationship between humans and Pokémon.
The movie presents an introspective approach that invites reflection on the value of life, free will, and the emotional connection between living beings. Through a journey filled with action and touching moments, themes such as identity, loneliness, and the struggle for acceptance are explored, offering a fresh perspective on a classic story that has resonated with generations, all enhanced by a modern animation style that continues to impress.