A renowned yet eccentric pathologist investigates a strange phenomenon affecting humans: an invisible parasite that feeds on fear. As he explores the world of horror, he discovers that this creature, which he names "The Tingler," manifests in people's spines when they experience extreme terror. However, the most unsettling aspect is that the Tingler can cause death if it is not released through a scream, and this disturbing revelation will soon unleash chaos.
The story takes a dark turn when a group of characters becomes trapped in a dizzying game between science and terror. With the help of a frightened young woman who becomes his assistant, the pathologist plans to experiment with the Tingler to better understand it. Things complicate when one of his subjects turns into a deadly enemy and a series of unexpected events unfold. In their struggle to stop this horror, the tension escalates, and the characters confront their own nature concerning fear.
As madness erupts on-screen in a blend of horror and comedy elements, the film also plays with the idea of audience interaction, elevating the cinematic experience to a completely new level. With shocking scenes and unexpected twists, it becomes a cult classic that addresses the power of the scream and terror as a form of survival.