In a vibrant Los Angeles of 1947, where pencils come to life and animated characters coexist with humans, a famous and exasperating rabbit named Roger is accused of a crime he didn't commit: the murder of his wife, Jessica Rabbit, a voluptuous femme fatale. Desperate to clear his name, Roger seeks the help of Eddie Valiant, a cynical private detective who hates "toons" after a personal tragedy. Reluctantly, Eddie agrees to help Roger.
As they delve into a world full of color and chaos, Eddie and Roger must solve a mystery involving a sinister plot that threatens all animated characters. Along the way, they encounter memorable villains and a sordid underworld of crime lurking in the shadows. The relationship between the detective and the rabbit, initially marked by distrust, evolves into an unexpected alliance that explores friendship and loyalty through absurd and dangerous situations.
Through spectacular action sequences and clever humor, the narrative intertwines the lives of the "toons" with the harsh reality of Hollywood at the time, highlighting the social struggles and discrimination they face. As the two protagonists unravel the conspiracy, they confront a truth that will change their lives forever, leaving a clear message: prejudice can distort the truth more than one can imagine.