In this wild sequel, the disasters of the gang of friends reach a climax when they find themselves in a more than complicated situation. After the debacles in Las Vegas and Thailand, the group has drifted a bit apart, but the magic of madness is still present. Alan, the crazy friend of the gang, is going through a tough time after the death of his father, and as part of his therapy, his friends decide to take him to a rehab center.
But, as always happens with these guys, the trip quickly derails from what was planned. Along the way, they are intercepted by a dangerous mobster looking to recover his brother, mysteriously connected to all of them. It's then that the dynamics of friendship are put to the test; with his brother kidnapped and a kind of chaos unleashed, the guys are forced to set a rescue plan in motion.
However, the problem is that every step they take drags them further into a series of hilarious and dangerous situations. From a fierce guard dog to outrageous supporting characters, the adventure soon becomes a bounty of craziness that only they could provoke. At its core, what is really being tested is loyalty, friendship, and the ability to survive another night of madness that will define their bonds forever. When all is said and done, will they really learn their lesson or continue to be trapped in their own rollercoaster of disasters?