In a world devastated by chaos and destruction, a new viral outbreak, more lethal than any before, threatens to turn humanity into an army of zombies as it wreaks havoc in the city of San Francisco. Leon S. Kennedy, the skilled government agent, heads to the city to investigate the origin of the outbreak and rescue a kidnapped scientist, whose knowledge of the pandemic is crucial. Along the way, he encounters Claire Redfield, who is also on a mission to save a group of survivors. Together, they must fight against hordes of infected and uncover a conspiracy that delves into the shadows of a ruthless corporation.
Meanwhile, Chris Redfield, Claire's brother and a veteran fighter, receives information about the possibility of a new biological weapon in the area. Joining forces with his friends, he becomes a vital force in the fight to dismantle this dangerous threat. Tension escalates as they uncover that a traitor lies among them, testing their loyalty and combat skills.
With every step, the group faces grotesque creatures and deadly traps in an environment where mistrust becomes their worst enemy. The story builds toward an explosive climax that will not only determine the fate of the characters but also the future of humanity itself. Will they be able to stop the biological disaster in time, or will it be too late to save themselves and those they love?