In the midst of the 1980s in New York City, Roberta Glass is an unhappy housewife feeling trapped in her monotonous lifestyle. One day, while flipping through a magazine, she comes across an intriguing ad about a mysterious woman named Susan, who is searching for a lost contact. Roberta, played by Rosanna Arquette, is so fascinated by Susan's vibrant and free-spirited life that she decides to follow her. Everything takes an unexpected turn when, after a strange encounter, Roberta becomes the victim of an accident that causes her to lose her memory.
Unsure of who she is or what has happened to her, Roberta is mistaken for Susan by several people, including a group of Susan's friends who are caught up in a mess of thefts and deceit. As Roberta begins to adopt Susan's carefree style, she is pulled into a world filled with fun, music, and unexpected conflicts. However, what started as a simple game of identities evolves into a profound quest for self-discovery.
While Susan, portrayed by Madonna, attempts to reclaim her life and confronts her own issues, Roberta and Susan's paths cross in a series of hilarious and heartfelt situations. Both women will learn valuable lessons about freedom, identity, and above all, human connection, all set against a funky backdrop filled with '80s fashion and an unforgettable soundtrack.