After a painful breakup with his girlfriend, a television star named Sarah Marshall, a music composer named Peter Bretter finds himself devastated and looking for a way to get over his heartbreak. Not knowing what else to do, he decides to take a vacation in Hawaii to try to piece his life back together and heal his heart. However, fate plays a cruel trick on him when he realizes that Sarah is also on vacation at the same resort, this time accompanied by her new and handsome boyfriend, a famous rocker.
As Peter tries to avoid his ex, his situation becomes even more complicated when he learns that his friends, whom he thought would be his unwavering support on this trip, have their own problems and are not much help. Amid a series of awkward encounters and hilarious moments, Peter runs into a charming yoga instructor who helps him rediscover fun and joy in life. Throughout this tropical adventure, Peter starts to realize that leaving his past behind is not just a matter of distance, but of courage and self-discovery. Among laughter, tears, and a good dose of music, our protagonist will learn that sometimes the best opportunities arise when you least expect them, and that moving on is the first step toward a new beginning.