When Larry Daley, the former night guard at the Museum of Natural History, becomes a successful businessman, he thinks his nights of adventure are behind him. However, chaos ensues when he learns that his beloved museum is about to be closed and the valuable artifacts will be taken to the Smithsonian Institution in Washington D.C. But what Larry doesn’t know is that things are not as calm there as they seem.
Upon arriving at the new museum, Larry discovers that his wax friends, like Teddy Roosevelt and the little dinosaur Rexy, are in danger due to an ancient artifact that has awakened a faction of historical figures ready to do evil. With the help of new and eccentric friends, such as Amelia Earhart and the famous artist Aladdin, Larry must fight against the wicked Kahmunrah, a pharaoh who seeks to rule the world using his supernatural powers.
The night transforms into a frantic battle between history and modernity, filled with action, humor, and cultural references. Larry must find a way to restore balance in the museum and save his friends while learning valuable lessons about friendship, courage, and the importance of valuing our roots. All of this takes place in a spectacular setting that combines the cultural richness of history with the fun of nocturnal adventures. Will Larry be able to save the day once again before dawn?