After their successful mission in high school, agents Schmidt and Jenko are sent to a college to infiltrate a mysterious drug trafficking case. Their task is to uncover who is behind a new and dangerous substance called "WHYPHY" that has started circulating among the students. The dynamic between the two partners remains hilarious, with Schmidt trying to mature and pursue a more serious relationship, while Jenko is swept away by college life, joining the football team and enjoying the party atmosphere.
As they progress in their mission, the agents find themselves caught in a whirlwind of comedic and absurd situations that test their friendship. With their opposite personalities, they face challenges that make them question their paths. While trying to unravel the network of criminals, they also have to deal with the intricacies of college life, from fraternities to young romances, adding another layer of chaos to their already complicated mission.
The laid-back humor and cultural references are constant, and the interactions between Schmidt and Jenko are what truly bring the story to life. In an action-packed and laugh-filled climax, the two are forced to team up like never before to stop the criminals and save the day, all while reflecting on what it really means to grow up and be friends in a world that always seems to be changing.