Andy Stitzer is a likable but somewhat awkward 40-year-old man who has spent his life working in an electronics store, surrounded by gadgets and video games, without ever experiencing love or intimacy. His life takes an unexpected turn when his coworkers discover his surprising secret: he is a virgin. Taking advantage of this revelation, his friends, who have been talking endlessly about their own sexual exploits, decide it's time to help him "lose his virginity." Thus begins a hilarious series of clumsy and comedic attempts to set Andy up with women, but everything seems to go wrong.
As his friends pressure him, Andy feels increasingly overwhelmed by the situation. However, fate has a twist in store for him when he meets a charming saleswoman at a collectibles store, who might just be the answer to his dreams of love. While he struggles to confront his emotional and sexual inexperience, Andy embarks on a journey of self-discovery, learning not only about sex but also what it truly means to form a genuine connection with someone.
With a stellar cast and unforgettable comedic moments, the film blends laughter with reflections on intimacy, friendship, and that peculiar moment in life when one realizes that sometimes it's better to take it slow and find what really matters.