In vibrant New York City, the Ninja Turtles—Leonardo, Michelangelo, Donatello, and Raphael—continue their fight against crime and delinquency while enjoying a life of adventures and pizza. However, their peace is threatened when a new danger emerges from the shadows. After a mysterious and unsettling substance known as "the ooze" comes into play, two classic villains reunite: the fearsome Shredder has returned, this time with a new ally, the formidable Tokka and Rahzar—mutant creatures created from the same material that brought the turtles to life.
With their home in jeopardy and the city plunged into chaos, the turtles must join forces once again to stop evil. While Donatello attempts to decipher the secret of the ooze to reverse the mutation of their enemies and protect their loved ones, his brothers must face not only the villains but also the doubts and challenges that come with adolescence. From comical rooftop brawls to thrilling encounters in the sewers, the band of friends embarks on a mission filled with action, laughter, and a strong message about family and acceptance.
With the help of April O'Neil and the brave Casey Jones, the turtles are ready to show that despite the obstacles, there is always a way out when working as a team.